The Peptide Melanotan-II Induces Erections in Men

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The Peptide Melanotan-II Induces Erections in Men

SYNTHETIC MELANOTROPIC PEPTIDE INITIATES ERECTIONS IN MEN WITH PSYCHOGENIC ERECTILE DYSFUNCTION: DOUBLE-BLIND, PLACEBO CONTROLLED CROSSOVER STUDY

The Journal of Urology

Volume 160, Issue 2, August 1998, Pages 389–393

(Note: Melanotan-2 is a peptide analogue of alpha-melanocyte stimulating hormone (a-MSH). When taken, melatonin stimulates the production of melanin which effectively absorbs light which then causes the skin to tan. It is currently being studied for its effectiveness as a tanning agent and aphrodisiac. Melanotan is not yet approved for prescription in the US)

Abstract

Purpose

We evaluated the erectogenic properties of a new cyclic alpha-melanocyte-stimulating hormone analogue, Melanotan-II, to treat men with psychogenic erectile dysfunction.>

Materials and Methods

Ten men with erectile dysfunction of no known organic cause were entered in a double-blind, placebo controlled crossover study in which the erectogenic properties of Melanotan-II and a vehicle placebo were compared using real-time RigiScan [double dagger] monitoring. The presence, duration and rigidity of erections were recorded during a 6-hour period.

Results

In 8 of 10 men treated with Melanotan-II clinically apparent erections developed. Mean duration of tip rigidity greater than 80% was 38.0 minutes with Melanotan-II and 3.0 with placebo (p = 0.0045). Transient side effects of nausea, stretching and yawning and decreased appetite were reported more frequently after injections of Melanotan-II than placebo but none required treatment.

Conclusions

Melanotan-II is a potent initiator of erections in men with psychogenic erectile dysfunction and has manageable side effects at a dose of 0.025 mg./kg.

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